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Prostate Cancer Risk and Testosterone Replacement Therapy

Tue, 05/01/2018 - 19:03 / By Andrew Rynne

Prostate Cancer Risk and Testosterone Replacement Therapy

Testosterone Replacement Therapy (TRT) does NOT increase your risk of developing prostate cancer. In face TRT has no bearing one way or the other on prostate cancer risk. And yet the myth to the contrary, the myth that TRT somehow increases prostate cancer risk, lives on. Nowhere is this dogma better up held than within the medical profession itself; among people who are supposed to know better.

This, in my view, is a terrible pity because there are a lot of older men out there who could potentially gain enormous benefit from testosterone therapy. And yet these men are being denied this often useful therapy by ignorant and prejudges doctors who base their opinion on a myth. I am thinking here now of mild depression, anxiety, low energy and loss of libido. Often such men are given antidepressants when in fact TRT might be more appropriate and indeed safer.

Very often, when I see older men in my clinic in Kildare, they have arrived there by a circuitous rout of uncooperative medical practitioners, doctors who have been self brainwashed into thinking that testosterone is somehow dangerous.

There are two good reasons for my being emphatic in saying that Testosterone Replacement Therapy does not increase the risk of prostate cancer:

  1. Prostate cancer is a disease of older men with declining levels of testosterone circulating in their bloodstream. It is not a disease of younger men with high levels of circulating testosterone. If testosterone was contribution to prostate cancer rates then you would expect to see the opposite to what is the case in reality.
  2. In a paper presented to the American Urology Association in 2016 a large study concluded as follows; 

  • Incidence of prostate cancer per 1,000 person-years was 2.27 among men who received testosterone treatment and 2.60 among those who never received treatment. Dr Malcolm Caruthers demonstrated the same thing years earlier.

Perhaps the following might explain how the myth that testosterone increase the risk of prostate cancer gained currency: When a man is diagnosed as having aggressive metastatic  prostate cancer he may be prescribed Finasteride. This is an anti-testosterone drug that usually buys the patient some time and brings about a temporary remission of his disease. So if less testosterone is good for prostate cancer then surely more testosterone is bad. That sort of twisted logic is called a corollary. and corollary has no place in science and certainly no place in medicine. 


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